abstract：:Peripheral neuropathic pain is a complex disease, and treated based on underlying diseases. Emerging evidences suggest that hyperbaric oxygen alleviates neuropathic pain. However, its cellular and molecular mechanism on pain relief is unknown. We hypothesize that hyperbaric oxygen alleviates neuropathic pain via activ...

journal_title：American journal of translational research

authors： Liu YD,Wang ZB,Han G,Zhao P

更新日期：2017-05-15 00:00:00

abstract：:Till now, no functional studies for FGF-16 in diabetic heart have been reported. Therefore, this study aims to evaluate the potential function of FGF-16 in inhibiting adverse cardiac remodeling in post myocardial infarction (MI) of diabetic heart. We investigated the role of fibroblast growth factor-16 (FGF-16) in pos...

journal_title：American journal of translational research

authors： Hu Y,Li L,Shen L,Gao H,Yu F,Yin W,Liu W

更新日期：2017-04-15 00:00:00

abstract：:Exosomes are small membrane vesicles with size of 30-100 nm, which were found in bodily fluids including amniotic fluid and saliva. The biological materials in exosomes, such as proteins and RNA, can be used as novel potential biomarkers for diagnostic assays. The purpose of this study was to assess whether exosomal m...

journal_title：American journal of translational research

authors： Xie J,Zhou Y,Gao W,Li Z,Xu Z,Zhou L

更新日期：2017-04-15 00:00:00

abstract：:MicroRNAs (miRNAs) have been involved in some human malignancies and correlated with tumor progression. The dysregulation of miR-130 is found in various cancers and correlated with tumor proliferation and apoptosis. However, its expression and function in non-small cell lung cancer (NSCLC) have not been investigated y...

journal_title：American journal of translational research

authors： Ye L,Wang Y,Nie L,Qian S,Xu M

更新日期：2017-04-15 00:00:00

abstract：:Erythema elevatum diutinum (EED) is a rare chronic inflammatory dermatosis and a part of the spectrum of cutaneous leukocytoclasticvasculitis. The most common site of involvement is extensor surface of the extremities, with a predilection for the skin overlying joints, particularly hands, feet, elbows and knees, as we...

journal_title：American journal of translational research

authors： Keyal U,Bhatta AK,Liu Y

更新日期：2017-04-15 00:00:00

abstract：OBJECTIVE:To create the rabbit animal model of intervertebral disc (IVD) degeneration by the annulus needle puncture technique through a novel transabdominal approach. METHODS:Thirteen New Zealand White rabbits underwent annular puncture at the L3/4, L4/5, and L5/6 discs through a transabdominal approach. For a longit...

journal_title：American journal of translational research

authors： Lei T,Zhang Y,Zhou Q,Luo X,Tang K,Chen R,Yu C,Quan Z

更新日期：2017-03-15 00:00:00

abstract：AIM:Geniposide is an iridoid glycoside isolated from the gardenia plant. It has multiple biological activities. The roles of geniposide in systemic sclerosis (SSc) and in endothelial-to-mesenchymal transition (EndMT) are unclear. We investigated the protective effects of geniposide in a bleomycin-induced SSc mouse mode...

journal_title：American journal of translational research

authors： Qi Q,Mao Y,Tian Y,Zhu K,Cha X,Wu M,Zhou X

更新日期：2017-03-15 00:00:00

abstract：:The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery...

journal_title：American journal of translational research

authors： Zong H,Li X,Lin H,Hou C,Ma F

更新日期：2017-03-15 00:00:00

abstract：:Objectives: Persistent low-grade chronic inflammation is common in type 2 diabetes (T2D) and obesity. To date, the underlying molecular mechanism is not well understood. In this study, we aimed to investigate gut microbiota and the expression of monocyte surface molecules in obese T2D subjects who underwent Roux-en-Y ...

journal_title：American journal of translational research

authors： Chen H,Qian L,Lv Q,Yu J,Wu W,Qian H

更新日期：2017-03-15 00:00:00

abstract：:The aim of this study was to investigate the in vivo and in vitro effects of miR-665 on sevoflurane anesthesia-induced cognitive dysfunction. SH-SY5Y cells and male SD rats were treated with sevoflurane to simulate anesthesia-induced cognitive dysfunction. The cells and rats both were transfected with a miR-665 mimic,...

journal_title：American journal of translational research

authors： Lu X,Lv S,Mi Y,Wang L,Wang G

更新日期：2017-03-15 00:00:00

abstract：:Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was desi...

journal_title：American journal of translational research

authors： Fedotova J,Akulova V,Pivina S,Dragasek J,Caprnda M,Kruzliak P

更新日期：2017-03-15 00:00:00

abstract：:Curcumin (Cur) has multiple pharmacological effects including antitumor, anti-inflammatory, antioxidant and cardiovascular protective effects. This research aims to further explore whether the cardiovascular protective effects of Cur are mediated by the miR-590-3p/CD40 pathway. Endothelial cells (ECs) were cultivated ...

journal_title：American journal of translational research

authors： Wu T,Xiang Y,Lv Y,Li D,Yu L,Guo R

更新日期：2017-02-15 00:00:00

abstract：:Neural Wiskott-Aldrich syndrome protein (N-WASP) is an important member of the WASP family involved in the actin cytoskeleton reorganization. Recent evidence suggests that N-WASP may play important roles in tumor progression and metastasis. However, the contribution of N-WASP to cervical cancer is still unknown. The p...

journal_title：American journal of translational research

authors： Hou J,Yang H,Huang X,Leng X,Zhou F,Xie C,Zhou Y,Xu Y

更新日期：2017-02-15 00:00:00

abstract：PURPOSE:This study aimed to determine the function of miR-15a in HCC, and identify cMyb as a target of miR-15a. METHODS:RNA expression was evaluated by quantitative real-time PCR (qRT-PCR). The effects of miR-15a or cMyb on HCC cells were evaluated by transwell migration assay and western blot analysis. CMyb, the pred...

journal_title：American journal of translational research

authors： Liu B,Sun T,Wu G,Shang-Guan H,Jiang ZJ,Zhang JR,Zheng YF

更新日期：2017-02-15 00:00:00

abstract：:The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are crucial pathological processes that are involved in atherosclerosis. Growing evidence suggests that microRNAs (miRNAs) play critical roles in VSMCs functions. Here, we analyzed the expression of four atherosclerosis-related miRNAs and...

journal_title：American journal of translational research

authors： Zhang X,Shi H,Wang Y,Hu J,Sun Z,Xu S

更新日期：2017-02-15 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a chronic disorder characterized by hepatic fat accumulation and abnormal lipid metabolism. Although miR-21 has been implicated in nonalcoholic fatty liver disease, it is unknown whether miR-21 could function as a therapeutic target. Here, we perform transfection analysis of...

journal_title：American journal of translational research

authors： Li CP,Li HJ,Nie J,Chen X,Zhou X

更新日期：2017-02-15 00:00:00

abstract：:Tetraspanin 12 (TSPAN12), as an earliest member of tetraspanin family, has been recently shown to be highly expressed in several malignant tumors, such as lung cancer and breast cancer, which plays an important role in regulating cell proliferation, migration and invasion. However, the functional roles of TSPAN12 in c...

journal_title：American journal of translational research

authors： Liu J,Chen C,Li G,Chen D,Zhou Q

更新日期：2017-02-15 00:00:00

abstract：:Lysine methylation plays a vital role in histone modification. Deregulations of lysine methyltransferases and demethylases have been frequently observed in human cancers. The SET and MYND domain containing protein 3 (SMYD3) is a novel histone lysine methyltransferase and it functions by regulating chromatin during the...

journal_title：American journal of translational research

authors： Huang L,Xu AM

更新日期：2017-01-15 00:00:00

abstract：BACKGROUND:Chondrogenic differentiation of mesenchymal stem cells (MSCs) is important for osteoarthritis (OA) treatment. However, the specific mechanisms involved are undefined. MicroRNAs (miRNAs) downregulate protein synthesis by binding to the 3'UTR of target mRNA. METHODS:Bone marrow aspirates were obtained from OA...

journal_title：American journal of translational research

authors： Zhang Y,Huang X,Yuan Y

更新日期：2017-01-15 00:00:00

abstract：:Aortic dissection (AD) is a life-threatening aortopathy with high mortality. To mimic spontaneous AD, investigate the pathogenesis of AD and develop novel therapeutic targets and measures, multiple AD experimental models have been generated, including drugs or chemicals induced experimental models, genetically modifie...

journal_title：American journal of translational research

authors： Jiang DS,Yi X,Zhu XH,Wei X

更新日期：2016-12-15 00:00:00

abstract：:Immune regulatory system dysfunction plays a role in the pathogenesis of asthma. The therapeutic effect of allergic asthma is to be improved. The immune regulatory function of probiotics has been recognized. This study tests a hypothesis that Clostridium butyricum (CB) enhances the effect of allergen specific immunoth...

journal_title：American journal of translational research

authors： Liu J,Chen FH,Qiu SQ,Yang LT,Zhang HP,Liu JQ,Geng XR,Yang G,Liu ZQ,Li J,Liu ZG,Li HB,Yang PC

更新日期：2016-12-15 00:00:00

abstract：:Angiotesin II (Ang II) plays an important role in cardiac remodeling. Fibroblast growth factor inducible-14 (Fn14) is the smallest member of the tumor necrosis factor superfamily of receptors. Currently, little is known about the functional role of Fn14 in the heart. Chiefly, we observe the up-regulation of extracellu...

journal_title：American journal of translational research

authors： Li Z,Shen Z,Du L,He J,Chen S,Zhang J,Luan Y,Fu G

更新日期：2016-12-15 00:00:00

abstract：:The objective of this paper was to investigate the suitability of the miniature pig as a large animal model of cochlear implantation (CI). Micro-CT scanning and three-dimensional reconstructions of the inner ear were completed in six animals. Photographs of the procedures and measurements of the inner ear were made. T...

journal_title：American journal of translational research

authors： Yi H,Guo W,Chen W,Chen L,Ye J,Yang S

更新日期：2016-12-15 00:00:00

abstract：:The aim of the study was to investigate the value of computed tomography (CT), magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) for diagnosing lymph nodes metastasis before treatment in gastric cancer. Eighty-two patients with proven gastric cancer underwent CT, morphological MRI (T2WI) and DWI ex...

journal_title：American journal of translational research

authors： Zhong J,Zhao W,Ren F,Qi S,Wang X,Lv T,Su Z,Yin H,Ren J,Huan Y

更新日期：2016-12-15 00:00:00

abstract：:Sepsis, the most severe manifestation of infection, poses a major challenge to health-care systems around the world. Limited ability to clean and remove the pathogen renders difficulty in septic patients to recover from the phase of immunoparalysis. The present study found the vital role of CX3CR1 internalization on s...

journal_title：American journal of translational research

authors： Ge XY,Fang SP,Zhou M,Luo J,Wei J,Wen XP,Yan XD,Zou Z

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:A meta-analysis was conducted to evaluate the accuracy of MRI, CT and FDG PET/CT in TNM stage of nasopharyngeal carcinoma patients (NPC). METHODS:Through a search of studies from 1996 to April 2015, pooled estimated sensitivity, specificity, pooled diagnostic odds ratio (DOR), summary receiver operating cha...

journal_title：American journal of translational research

authors： Chen WS,Li JJ,Hong L,Xing ZB,Wang F,Li CQ

更新日期：2016-11-15 00:00:00

abstract：:Heaptocellular carcinoma (HCC) is still a great health problem around the world. Recently, the cetuximab has been implicated to have therapeutic values for HCC. However, cetuximab-resistance has also been synchronously reported pertaining to HCC treatment. This study aimed to evaluate the role of eIF5A2 in cetuximab-t...

journal_title：American journal of translational research

authors： Xue F,Liu Y,Chu H,Wen Y,Yan L,Tang Q,Xiao E,Zhang D,Zhang H

更新日期：2016-11-15 00:00:00

abstract：:Background: Hypoxia has been reported to possess the ability to induce mature lipid-filled adipocytes to differentiate into fibroblast-like multipotent dedifferentiated fat (DFAT) cells and stem cells such as iPSCs (interstitial pluripotent stem cells) and ESCs (embryonic stem cells) and then to differentiate into car...

journal_title：American journal of translational research

authors： Li F,Li Z,Jiang Z,Tian Y,Wang Z,Yi W,Zhang C

更新日期：2016-11-15 00:00:00

abstract：:miR-101 is significantly downregulated in various human cancers, including oral squamous cell carcinoma (OSCC). However, the role of miR-101 in OSCC has not been elucidated. In this study, miR-101 lowly expressed in OSCC tissues and cell lines compared with that in adjacent normal tissues and human normal oral keratin...

journal_title：American journal of translational research

authors： Hui Y,Li Y,Jing Y,Feng JQ,Ding Y

更新日期：2016-11-15 00:00:00

abstract：:The exact roles of copy number alteration (CNA) in initiation, progression and immunotherapy of breast cancer and the genomic alterations behind progression from ductal carcinoma in situ (DCIS) to invasive carcinoma remain unknown. Quantitative multi-gene fluorescence in situ hybridization (QM-FISH) opens a possibilit...

journal_title：American journal of translational research

authors： Pan A,Zhou Y,Mu K,Liu Y,Sun F,Li P,Li L

更新日期：2016-11-15 00:00:00

abstract：:The present study aimed to investigate the effect of genetic polymorphisms of catechol-O-methyl transferase (COMT), apolipoprotein E (APOE), and brain derived neurotrophic factor (BDNF) on the modulation of the chemotherapy-induced cognitive impairment (CICI) in breast cancer patients. Eighty triple negative breast ca...

journal_title：American journal of translational research

authors： Cheng H,Li W,Gan C,Zhang B,Jia Q,Wang K

更新日期：2016-11-15 00:00:00

abstract：:The purpose of the present study was to assess the ocular surface health status in primary open angle glaucoma (POAG) patients switching from topical application of preserved latanoprost (LT) to preservative-free tafluprost (PFT) by tear proteomic monitoring. Tear fluid of POAG patients showing dry eye symptoms, using...

journal_title：American journal of translational research

authors： Funke S,Beck S,Lorenz K,Kotterer M,Wolters D,Perumal N,Pfeiffer N,Grus FH

更新日期：2016-10-15 00:00:00

abstract：:Atorvastatin (ATV) has an important pro-survival role in cardiomyocytes after acute myocardial infarction (AMI). The objectives of this study were to: 1) determine whether ATV could affect autophagy of cardiomyocytes via the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, and 2) inves...

journal_title：American journal of translational research

authors： Li Q,Dong QT,Yang YJ,Tian XQ,Jin C,Huang PS,Jiang LP,Chen GH

更新日期：2016-10-15 00:00:00

abstract：OBJECTIVE:Our overall goal was to investigate the anti-tumor activity of the glutaminase 1 (GLS1) Inhibitor compound 968 in ovarian cancer cells. The human ovarian cancer cell lines, HEY, SKOV3 and IGROV-1 were used. Cell proliferation was assessed by MTT assay after treatment with compound 968. Cell cycle progression ...

journal_title：American journal of translational research

authors： Yuan L,Sheng X,Clark LH,Zhang L,Guo H,Jones HM,Willson AK,Gehrig PA,Zhou C,Bae-Jump VL

更新日期：2016-10-15 00:00:00

abstract：:Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin l...

journal_title：American journal of translational research

authors： Garrigan C,Han J,Tolomeo P,Johnson KJ,Master SR,Lautenbach E,Nachamkin I

更新日期：2016-10-15 00:00:00

abstract：BACKGROUND:Colorectal cancer is prevalent worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a public dataset...

journal_title：American journal of translational research

authors： Chai CY,Zhang Y,Song J,Lin SC,Sun S,Chang IW

更新日期：2016-10-15 00:00:00

abstract：OBJECTIVE:To investigate the effects of paeoniflorin, the main monomer component of Jinxueyuan granules, on the Ca2+ concentrations in salivary gland cells to further explore the salivation-promoting mechanism and effective monomer components of Jinxueyuan granules. METHODS:The salivary gland cells of suckling rats we...

journal_title：American journal of translational research

authors： Qian X,Shi X,Wang H

更新日期：2016-09-15 00:00:00

abstract：:Gastric cancer (GC) causes nearly one million deaths worldwide each year. However, the molecular pathway of GC development remains unclear. Increasing evidences have shown that microRNAs (miRNAs) are highly associated with tumor development. However, relative little is known about the potential role of miRNAs in gastr...

journal_title：American journal of translational research

authors： Qian K,Mao B,Zhang W,Chen H

更新日期：2016-09-15 00:00:00

abstract：:Reduced placental growth factor (PLGF) during pregnancy is known to be a reason for developing preeclampsia (PE) and gestational diabetes mellitus (GDM), but the underlying mechanisms remain unclear. Recently, it has been shown that reduced PLGF may induce GDM through suppressing beta-cell mass growth in a PI3k/Akt si...

journal_title：American journal of translational research

authors： Xu X,Shen J

更新日期：2016-09-15 00:00:00

abstract：:As two major non-operative methods, physiotherapy and acupuncture have been proved to be safe and effective in osteoarthritis (OA) treatment. However, only a little study focused on functions of both methods on cartilage repairing. The main goal of this research is to prove and compare effectiveness of acupuncture and...

journal_title：American journal of translational research

authors： Zhang Y,Bao F,Wang Y,Wu Z

更新日期：2016-09-15 00:00:00